Hutchinson-Gilford Progeria Syndrome

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare disease, associated with premature aging. It only affects 1 per 4-8 million live births across the world. It is common for people with HGPS to appear normal at birth, but then they commonly develop accelerated aging symptoms, including shortened stature, facial disproportion, thin skin, alopecia (hair loss), […]

Quantitative study of the selectivity of human sirtuins to acylated nucleosomes

Visit the full literature paper here: https://www.nature.com/articles/s41598-018-21060-2.pdf As we have learned for essentially our entire college experience, chromatin is regulated by post-translational modifications (PTMs) of the histones in nucleosomes. Most commonly, we hear about the acetylation of histones in regards to PTMs and how it is essential in the activation of gene expression. This is accomplished […]

Reflection Blog 3: Organization of Literature

I have gathered many sources from the literature on Hutchinson-Gilford Progeria Syndrome (HGPS), my disease of choice for the bcm441 disease project. This disease is associated with premature aging. This literature I have collected is all fairly recent, majority of it coming from the last 15 years, as I have sources from 2003 to 2018. […]

Metabolic Enzyme Regulates Histone Acetylation and Spatial Memory

https://www.nature.com/articles/nature22405.pdf Epigenetic modifications have been identified in cognitive processing, specifically in learning and memory. Lack of histone acetylation has been implicated in neurodevelopmental disorders, neurodegeneration, and aging.1 Expression of neuronal genes that are involved in chromatin modification processes, such as histone acetylation, have important involvement in storing and forming memories, mostly in the hippocampus. Transcription […]

Disease Project

There are a few diseases that I find an interest in and would potentially like to pursue my bcm441 project on. Hutchinson-Gilford progeria syndrome is an autosomal dominant disease that causes children to look like they are aging. There are so many complications that are involved with this disease and it is extremely rare. This […]

“The role of fatty acid β-oxidation in lymphangiogenesis” Spotlight

Acetyl CoA has many different roles in various pathways, serving in making energy, biosynthesis, and in post-transnational modifications controlling epigenetic gene expression. Wong et al. covers the role of fatty acid beta-oxidation in lymphatic endothelial cells (LECs) in generating Acetyl CoA for the purpose of acetylating histones in lymphangiogenesis.  Carnitine palmitoyl-transferase 1 (CPT1) converts acyl […]

Why biochemistry?

What does it mean to study biochemistry? To study biochemistry, is to study various chemical implications in biological systems (or living things). Biochemistry makes up various fields that all generally study the molecules and the mechanisms that these molecules participate in that allow biological systems to work and function properly (or improperly, for that matter). […]